The Microbiota-Gut-Brain Axis: From Motility to Mood

Gastroenterology. 2021 Jan 22;S0016-5085(21)00268-7.doi: 10.1053/j.gastro.2020.10.066. Online ahead of print.

Kara G Margolis 1, John F Cryan 2, Emeran A Mayer 3


Author information

  • 1Department of Pediatrics, Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY;. Electronic address: Kjg2133@cumc.columbia.edu.
  • 2Department of Anatomy & Neuroscience, University College Cork, Ireland, APC Microbiome Ireland, University College Cork, Ireland.
  • 3G. Oppenheimer Center for Neurobiology of Stress and Resilience, Vachte and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California.


The gut-brain axis plays an important role in maintaining homeostasis. Many intrinsic and extrinsic factors influence signaling along this axis, modulating the function of both the enteric and central nervous systems. More recently the role of the microbiome as an important factor in modulating gut-brain signaling has emerged and the concept of a microbiota-gut-brain axis has been established. In this review, we highlight the role of this axis in modulating enteric and central nervous system function and how this may impact disorders such as Irritable Bowel Syndrome and disorders of mood and affect. We examine the overlapping biological constructs that underpin these disorders with a special emphasis on the neurotransmitter serotonin, which plays a key role in both the gastrointestinal tract and in the brain. Overall, it is clear that although animal studies have shown much promise, more progress is necessary before these findings can be translated for diagnostic and therapeutic benefit in patient populations.

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