Abstract

Intake of dietary fibre, red and processed meat and risk of late-onset Chronic Inflammatory Diseases: A prospective Danish study on the "diet, cancer and health" cohort

Int J Med Sci. 2020 Sep 9;17(16):2487-2495. doi: 10.7150/ijms.49314. eCollection 2020.

Katrine Hass Rubin 1, Nathalie Fogh Rasmussen 2, Inge Petersen 1, Tine Iskov Kopp 3 4, Egon Stenager 5 6, Melinda Magyari 4 7, Merete Lund Hetland 8 9, Anette Bygum 10 11, Bente Glintborg 8 9, Vibeke Andersen 2 12 13

 
     

Author information

  • 1OPEN - Open Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark, and Odense University Hospital, Odense Denmark.
  • 2Focused Research Unit for Molecular Diagnostic and Clinical Research, IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark.
  • 3Danish Cancer Society Research Centre, Copenhagen, Denmark.
  • 4The Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmarkarch, University of Southern Denmark, Odense.
  • 5MS clinic of Southern Jutland (Sønderborg, Esbjerg, Kolding) University Hospital of Southern Jutland, DK-6200 Aabenraa, Denmark.
  • 6Department of Regional Health Research, University of Southern Denmark, DK-5000 Odense C, Denmark.
  • 7National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
  • 8The DANBIO registry and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Center of Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.
  • 9Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen.
  • 10Department of Clinical Genetics, Odense University Hospital, Odense, Denmark; University of Southern Denmark, Odense, Denmark.
  • 11Research Unit of Dermato-Venerology, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • 12Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • 13Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

Abstract

Background: Human and animal studies support the involvement of diet in the development of CID -chronic inflammatory diseases such as inflammatory bowel disease, psoriasis, rheumatoid arthritis, psoriatic arthritis, and multiple sclerosis. Objective: This cohort study aimed to investigate the association between intake of fibre, red and processed meat, and occurrence of late-onset CID (50+ years of age) in the DCH: Danish Diet, Cancer and Health cohort. We hypothesised that risk of late-onset CID would be lower among those with high intake of fibre and/or low intake of meat compared to individuals with low fibre and/or high meat intake. Methods:The DCH recruited 56,468 individuals, aged 50-64 years, between 1993 and 1997. At recruitment, diet intake was registered using food frequency questionnaires as well as lifestyle factors in 56,075 persons. Exposure variables were generated as sex-adjusted tertiles of fibre and meat (g/day). Development of CIDs was identified in national registries. Hazard ratios (HR) of late-onset CIDs (adjusted for age, sex, energy intake, alcohol, smoking, education, comorbidity, and civil status) were estimated for all three exposure variables. Results: During follow-up of 1,123,754 years (median (Interquartile range) = 22.2 (20.1-23.1)), 1,758 (3.1%) participants developed at least one CID. The adjusted HRs for developing CID (low fibre 1.04 [0.89-1.22] and medium fibre 1.04 [0.91-1.18] (high fibre as reference), and medium meat 0.96 [0.86-1.09] and high meat 0.94 [0.82-1.07] (low meat as reference)) or the individual diseases were not statistically significant. Conclusion:This large study did not support that a high intake of fibre and/or a low intake of meat had a high impact on the risk of late-onset CID.

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