- Fecal Incontinence
|Disease and Treatment Patterns Among Patients With Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States
Crohns Colitis 360. 2020 Jul;2(3):otaa039. doi: 10.1093/crocol/otaa039. Epub 2020 Jul 24.
Edward L Barnes 1 2 3, Laura Raffals 4, Millie D Long 1 2 3, Gaurav Syal 5, Maia Kayal 6, Ashwin Ananthakrishnan 7, Benjamin Cohen 6, Joel Pekow 8, Parakkal Deepak 9, Jean-Frederic Colombel 6, Hans H Herfarth 1 2 3, Robert S Sandler 1 2
Background: Gaps exist in our understanding of the clinical course of pouch-related disorders.
Methods: We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch.
Results: Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery.
Conclusions: Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system.