Abstract

Management of Acute Severe Ulcerative Colitis in a Pregnant Woman With COVID-19 Infection: A Case Report and Review of the Literature

Inflamm Bowel Dis. 2020 May 12;izaa109.doi: 10.1093/ibd/izaa109. Online ahead of print.

Melissa H Rosen 1, Jordan Axelrad 1, David Hudesman 1, David T Rubin 2, Shannon Chang 1

 
     

Author information

1Division of Gastroenterology and Hepatology, NYU Langone Health, New York, NY.

2University of Chicago Medicine Inflammatory Bowel Disease Center, Chicago, IL.

Free PMC article

Abstract

First detected in Wuhan, China, the novel 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped RNA beta-coronavirus responsible for an unprecedented, worldwide pandemic caused by COVID-19. Optimal management of immunosuppression in inflammatory bowel disease (IBD) patients with COVID-19 infection currently is based on expert opinion, given the novelty of the infection and the corresponding lack of high-level evidence in patients with immune-mediated conditions. There are limited data regarding IBD patients with COVID-19 and no data regarding early pregnancy in the era of COVID-19. This article describes a patient with acute severe ulcerative colitis (UC) during her first trimester of pregnancy who also has COVID-19. The case presentation is followed by a review of the literature to date on COVID-19 in regard to inflammatory bowel disease and pregnancy, respectively.

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