F1000Res. 2020 Apr 24;9:F1000 Faculty Rev-294.doi:10.12688/f1000research.20805.1. eCollection 2020.

Ross J Porter ¹, Rahul Kalla ¹, Gwo-Tzer Ho ¹

Author information

¹Edinburgh IBD Science Unit, Centre for Inflammation Research, Queens Medical Research Unit, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.

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Abstract

Inflammatory bowel diseases are common, complex, immune-mediated conditions with a sharply rising global prevalence. While major advances since 2000 have provided strong mechanistic clues implicating a de-regulation in the normal interaction among host genetics, immunity, microbiome, and the environment, more recent progress has generated entirely new hypotheses and also further refined older disease concepts. In this review, we focus specifically on these novel developments in the pathogenesis of ulcerative colitis.