- Fecal Incontinence
|Inflammatory Cutaneous Lesions in Inflammatory Bowel Disease Treated With Vedolizumab or Ustekinumab: An ECCO CONFER Multicentre Case Series
J Crohns Colitis. 2020 Apr 22;jjaa078. doi: 10.1093/ecco-jcc/jjaa078. Online ahead of print.
F M Phillips 1, B Verstockt 2 3, S Sebastian 4 5, D G Ribaldone 6, S Vavricka 7, K Katsanos 8, E Slattery 9, N de Suray 10 11, C Flores 12, W Fries 13, F Vincenzi 14, E Capoferro 14 15, O Bachmann 16, U Kopylov 17, ECCO CONFER investigators
1NIHR Nottingham Digestive Diseases Biomedical Research Centre, Nottingham University Hospitals, Nottingham, UK.
2University Hospitals Leuven, Gastroenterology and Hepatology, Leuven, Belgium.
3KU Leuven, Chronic Diseases, Metabolism and Ageing, TARGID-IBD unit, Leuven, Belgium.
4Hull and East Yorkshire Hospitals NHS Trust, Inflammatory Bowel Disease Unit, Hull, UK.
5University of Hull and York, Hull York Medical School, Hull, UK.
6University of Turin, Surgical Sciences, Turin, Italy.
7University Hospital Zurich, Medicine, Zurich, Switzerland.
8University of Ioannina School of Medical Sciences, Gastroenterology, Ioannina, Greece.
9University Hospital Galway, Gastroenterology, Galway, Ireland.
10Grand Hopital de Charleroi, Gastroenterology and Hepatology, Charleroi, Belgium.
11University Hospital Saint-Luc, Gastroenterology and Hepatology, Bruxelles, Belgium.
12Hospital de Clinicas de Porto Alegre, Gastroenterology, Rio Grande do Sul, Brazil.
13University Messina, Clinical Unit for Chronic Bowel Disorders, Messina, Italy.
14University of Parma, Gastroenterology and Endoscopy Unit, Parma, Italy.
15Sacro Cuore Don Calabria of Negrar, Negrar, Italy.
16Siloah St. Trudpert Klinikum, Pforzheim, Germany.
17Sheba Medical Centre, Gastroenterology, Ramat Gan, Israel.
This was a multicentre case series supported by the European Crohn's and Colitis Organisation (ECCO) and, performed as part of the Collaborative Network of Exceptionally Rare case reports (CONFER) project. The aim was to report on whether cutaneous lesions associated with inflammatory bowel disease (IBD) and refractory to standard medical therapy including anti-TNFs, would respond to the newer biologic agents Ustekinumab (UST) or Vedolizumab (VDZ). This report includes 28 patients with cutaneous lesions form 14 centres, all of whom had failed immunomodulator and anti-TNF therapy. Metastatic Crohn's disease (MCD) was diagnosed in 10 patients: UST led to remission in 5 cases and partial response in 4 cases, with a single report of VDZ inducing remission. All cases of MCD treated with UST responded after the first or second dose, whilst the median time for the 5 cases that attained remission was 5 months. Pyoderma gangrenosum (PG) was diagnosed in 4 cases: 3 of these attained remission with UST (median time to remission 4 months) whilst one case did not respond to VDZ. There were 7 cases of erythema nodosum (EN): UST led to remission in 4 cases and partial response in 1 case whilst VDZ had partial response in 2 cases and non-response in 2 cases. There were 7 single cases of other inflammatory lesions. In summary, UST appears to be useful for different cutaneous lesions including MCD, PG and EN, whilst VDZ does not appear to be useful for lesions that are independent of disease activity.