Inflammatory Bowel Disease: A Nationwide Study of Hip Fracture and Mortality Risk after Hip Fracture

Bartko J1, Reichardt B2, Kocijan R1, Klaushofer K1, Zwerina J1, Behanova M1. J Crohns Colitis. 2020 Mar 14. pii: jjaa052. doi: 10.1093/ecco-jcc/jjaa052. [Epub ahead of print]


Author information

Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of OEGK and AUVA Trauma Centre Meidling, 1st Med. Dept. Hanusch Hospital, Vienna, Austria.

Austrian Social Health Insurance Fund, Österreichische Gesundheitskasse, Siegfried Marcus Straße, Eisenstadt, Austria.


BACKGROUND AND AIMS: With rising rates of inflammatory bowel diseases (IBD) in older adults, management of co-morbidities such as osteoporosis is becoming increasingly important. Hip fracture (HF) is the most serious consequence of low bone mineral quality and is associated with excess risk of mortality. For older IBD patients, there are only limited data available. Therefore, we aimed to assess the association of IBD with HF and all-cause mortality risk after HF among IBD patients older than 50 years.

METHODS: In a national database-registered case-control study, 56,821 HF cases aged ≥50 years and 113,718 age-, sex- and region-matched non-hip fracture controls were analyzed between 2012-2016. A history of IBD was assessed from data of Austrian social health insurance funds. Logistic regression and Cox proportional multivariate models were used to test the association of IBD with HF and post-hip fracture mortality risk.

RESULTS: A total of 531 patients were identified with IBD (25.0% men, mean age 81.2 years, SD 9.7). Analysis adjusted for anti-osteoporotic treatment, use of glucocorticoids and selected medications showed that IBD patients had an increased odds of HF (OR 2.22, 95%CI 1.86-2.64). Patients with Crohn's disease (CD) revealed a higher HF odds in contrast to patients with ulcerative colitis (OR 2.91, 95% CI 2.17-3.89 and OR 1.89, 95% CI 1.52-2.35, respectively). Overall mortality risk after HF was higher among female CD patients (HR 1.75, 95%CI 1.28-2.41) than in the general population.

CONCLUSIONS: IBD was strongly associated with HF in older patients. Post-hip fracture mortality risk was elevated particularly in women with CD.

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