Abstract

Pre-treatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients with Inflammatory Bowel Diseases

Kochar B1, Cai W2, Cagan A3, Ananthakrishnan AN4. Gastroenterology. 2020 Feb 24. pii: S0016-5085(20)30243-2. doi: 10.1053/j.gastro.2020.02.032. [Epub ahead of print]

 
     

Author information

1 Division of Gastroenterology, Massachusetts General Hospital, Boston, MA; Clinical Translational Epidemiology Unit, The Mongan Institute, Boston, MA.

2 Division of Gastroenterology, Massachusetts General Hospital, Boston, MA.

3 Partners Healthcare, Boston, MA.

4 Division of Gastroenterology, Massachusetts General Hospital, Boston, MA; Clinical Translational Epidemiology Unit, The Mongan Institute, Boston, MA. Electronic address: aananthakrishnan@mgh.harvard.edu.

Abstract

BACKGROUND & AIMS: Infections are an important adverse effect of immunosuppression for treatment of inflammatory bowel diseases (IBD). However, risk of infection cannot be sufficiently determined based on patients' age or comorbidities. Frailty has been associated with outcomes of patients with other inflammatory diseases. We aimed to determine the association between frailty and risk of infections after immunosuppression for IBD.

METHODS: We performed a cohort study of 11,001 patients with IBD, using a validated frailty definition based on International Classification of Disease codes to identify patients who were frail vs fit in the 2 y before initiation of an anti-tumor necrosis factor (TNF) or immunomodulator therapy, from 1996 through 2010. Our primary outcome was an infection in the first year after treatment. We constructed multivariable logistic regression models, adjusting for clinically pertinent confounders (age, comorbidities, steroid use, and combination therapy) to determine the association between frailty and post-treatment infections.

RESULTS: There were 1299 patients treated with an anti-TNF agent and 2676 patients treated with an immunomodulator. In this cohort, 5% of patients who received anti-TNF therapy and 7% of patients who received an immunomodulator were frail in the 2 y before immunosuppression. Frail patients were older and had more comorbidities. Higher proportions of frail patients developed infections after treatment (19% after TNF and 17% after immunomodulators) compared with fit patients (9% after TNF and 7% after immunomodulators; P<.01 for frail vs fit in both groups). Frail patients had an increased risk of infection after we adjusted for age, comorbidities, and concomitant medications (anti-TNF adjusted odds ratio, 2.05; 95% CI, 1.07-3.93 and immunomodulator adjusted odds ratio, 1.81; 95% CI, 1.22-2.70).

CONCLUSIONS: Frailty is associated with infections after immunosuppression in patients with IBD, after we adjust for age and comorbidities. Systematic assessment and strategies to improve frailty might reduce infection risk in patients with IBD.

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