Dorfman L^1,2, Ghersin I³, Khateeb N⁴, Daher S⁴, Shamir R^1,2, Assa A^1,2. Acta Paediatr. 2020 Feb 19. doi: 10.1111/apa.15237. [Epub ahead of print]

Author information

1 Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center, Petach Tikva, Israel.

2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

3 Department of Internal Medicine B/H, Rambam Health Care Campus, Haifa, Israel.

4 Medical Corps, Israeli Defense Forces, Tel Aviv, Israel.

Abstract

AIM: Due to conflicting data, we aimed to investigate the association of inflammatory bowel disease (IBD) with cardiovascular disease (CVD) risk factors at late adolescence in a cross-sectional population-based study.

METHODS: A total of 1 144 213 Jewish Israeli adolescents who underwent a general health examination prior to enlistment at median age of 17.1 years from 1988 to 2016 were included. Covariate data included demographics, blood pressure, resting heart rate and risk factors associated with CVD.

RESULTS: Overall, 2372 cases of IBD were identified, including 1612 cases of Crohn's disease (68%). Univariate analysis showed marginally lower systolic and diastolic blood pressure in patients with IBD with no difference following multivariate analysis. Diagnosis of Crohn's disease in males was associated with lower rates of overweight (15.8% vs 21.2%, P < .001) and obesity (3.7% vs 6.1% P = .003), whereas females with Crohn's disease had a lower rate of overweight (14.0% vs 17.9% P = .04) but not obesity. Patients with ulcerative colitis did not differ from controls in terms of overweight or obesity. Patients with Crohn's disease had an increased prevalence of hereditary hypercoagulability (odds ratio 16.9, 95% confidence interval 8.0-35.7, P < .001).

CONCLUSION: Significant risk factors for CVD were not present in adolescents with IBD.