Abstract

Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery

Weaver KN1Kochar B1,2Hansen JJ1,2,3Isaacs KL1,2,3Jain A1,2,3Sheikh SZ1,2,3Fichera A2,4Chaumont N2,4Sadiq T2,4Koruda M2,4Long MD1,2,3Herfarth HH1,2,3Barnes EL1,2,3. Crohns Colitis 360. 2019 Oct;1(3):otz029. doi: 10.1093/crocol/otz029. Epub 2019 Sep 26.

 
     

Author information

Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Multidisciplinary Center for Inflammatory Bowel Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Division of Gastrointestinal Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Abstract

BACKGROUND: Risk factors for the development of chronic antibiotic dependent pouchitis (CADP) are not well understood.

METHODS: Using multivariable logistic regression, we compared clinical factors between 194 patients with acute antibiotic responsive pouchitis or CADP.

RESULTS: Individuals with CADP were significantly older (40.9 vs 30.8 years, P < 0.001) and demonstrated a longer diseaseduration before IPAA (10.3 vs 7.0 years, P = 0.004). Age ≥55 years at the time of IPAA was significantly associated with CADP (adjusted odds ratio = 4.35, 95% confidence interval = 1.01-18.7).

CONCLUSIONS: Although older age should not represent a barrier to IPAA, further studies evaluating etiologies of this association are warranted.

© Copyright 2013-2020 GI Health Foundation. All rights reserved.
This site is maintained as an educational resource for US healthcare providers only. Use of this website is governed by the GIHF terms of use and privacy statement.