- Fecal Incontinence
|Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery
Weaver KN1, Kochar B1,2, Hansen JJ1,2,3, Isaacs KL1,2,3, Jain A1,2,3, Sheikh SZ1,2,3, Fichera A2,4, Chaumont N2,4, Sadiq T2,4, Koruda M2,4, Long MD1,2,3, Herfarth HH1,2,3, Barnes EL1,2,3. Crohns Colitis 360. 2019 Oct;1(3):otz029. doi: 10.1093/crocol/otz029. Epub 2019 Sep 26.
1 Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
2 Multidisciplinary Center for Inflammatory Bowel Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC.
3 Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC.
4 Division of Gastrointestinal Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
BACKGROUND: Risk factors for the development of chronic antibiotic dependent pouchitis (CADP) are not well understood.
METHODS: Using multivariable logistic regression, we compared clinical factors between 194 patients with acute antibiotic responsive pouchitis or CADP.
RESULTS: Individuals with CADP were significantly older (40.9 vs 30.8 years, P < 0.001) and demonstrated a longer diseaseduration before IPAA (10.3 vs 7.0 years, P = 0.004). Age ≥55 years at the time of IPAA was significantly associated with CADP (adjusted odds ratio = 4.35, 95% confidence interval = 1.01-18.7).
CONCLUSIONS: Although older age should not represent a barrier to IPAA, further studies evaluating etiologies of this association are warranted.