Abstract

The Gut Microbiome in Inflammatory Bowel Disease: Lessons Learned From Other Immune-Mediated Inflammatory Diseases

Knox NC1,2, Forbes JD3,4, Peterson CL1, Van Domselaar G1,2, Bernstein CN4,5. Am J Gastroenterol. 2019 Jul;114(7):1051-1070. doi: 10.14309/ajg.0000000000000305.

 
     

Author information

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.

Department of Medical Microbiology & Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.

Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.

IBD Clinical and Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.

Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

Abstract

There is a growing appreciation for the role of the gut microbiome in human health and disease. Aided by advances in sequencing technologies and analytical methods, recent research has shown the healthy gut microbiome to possess considerable diversity and functional capacity. Dysbiosis of the gut microbiota is believed to be involved in the pathogenesis of not only diseases that primarily affect the gastrointestinal tract but also other less obvious diseases, including neurologic, rheumatologic, metabolic, hepatic, and other illnesses. Chronic immune-mediated inflammatory diseases (IMIDs) represent a group of diseases that share many underlying etiological factors including genetics, aberrant immunological responses, and environmental factors. Gut dysbiosis has been reported to be common to IMIDs as a whole, and much effort is currently being directed toward elucidating microbiome-mediated disease mechanisms and their implications for causality. In this review, we discuss gut microbiome studies in several IMIDs and show how these studies can inform our understanding of the role of the gut microbiome in inflammatory bowel disease.

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