Abstract

The vitamin D positive feedback hypothesis of inflammatory bowel diseases

Linneman Z1, Reis C1, Balaji K2, Moore J2, Braude S3. Med Hypotheses. 2019 Jun;127:154-158. doi: 10.1016/j.mehy.2019.04.005. Epub 2019 Apr 16.

 
     

Author information

Biology Department, Washington University, United States.

Radiation Oncology, Washington U. School of Medicine, United States.

Biology Department, Washington University, United States. Electronic address: braude@wustl.edu.

Abstract

While it appears that there are a variety of factors that exacerbate IBD, it is frustrating that symptoms can persist and worsen even when environmental insults are removed. We suggest that there may be a positive feedback loop which perpetuates the inflammatory response in IBD patients. The loop is triggered by vitamin D deficiency which reduces calcium uptake. Lowered vitamin D and calcium interfere with anti-inflammatory pathways. Inflammation of the mucosa inhibits absorption of calcium and thus perpetuates the reduced anti-inflammatory response. A number of predictions follow from this hypothesis and are supported by geographic and lifestyle patterns in IBD incidence and prevalence.

© Copyright 2013-2019 GI Health Foundation. All rights reserved.
This site is maintained as an educational resource for US healthcare providers only. Use of this website is governed by the GIHF terms of use and privacy statement.