Treat-to-Target in Inflammatory Bowel Diseases, What Is the Target and How Do We Treat?

Agrawal M1, Colombel JF2. Gastrointest Endosc Clin N Am. 2019 Jul;29(3):421-436. doi: 10.1016/j.giec.2019.02.004. Epub 2019 Apr 6.


Author information

Division of Gastroenterology, Lenox Hill Hospital, Northwell Health, 100 East 77th Street, New York, NY 10075, USA. Electronic address: magrawal1@northwell.edu.

Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, 1428 Madison Avenue, New York, NY 10029, USA.


Inflammatory bowel diseases, including Crohn disease (CD) and ulcerative colitis (UC), are chronic, progressive, immune-mediated inflammatory diseases of the gastrointestinal tract. Early therapy using a treat-to-target (T2T) approach, which implies identification of a pre-defined target, followed by optimization of therapy and regular monitoring until the goal is achieved is critical in preventing adverse long-term outcomes. In this review, the authors discuss the T2T guidance developed by the Selecting Therapeutic Targets in Inflammatory Bowel Disease committee, new evidence published on the role of various targets in CD and UC, as well as the real-world applicability of T2T."

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