Assessment of the procoagulant potential and associated risk factors in pregnant patients with inflammatory bowel diseases

Rottenstreich A1, Diminsky M2, Granovsky SG3, Mishael T3, Roth B4, Spectre G5, Kalish Y4, Goldin E3, Shitrit AB3. Eur J Intern Med. 2019 Apr 26. pii: S0953-6205(19)30119-0. doi: 10.1016/j.ejim.2019.04.013. [Epub ahead of print]


Author information

Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address: amichaimd@gmail.com.

Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

IBD MOM Unit, Digestive Diseases Institute, Shaare Zedek Medical Center, Affiliated with the Medical School, Hebrew University, Jerusalem, Israel.

Hematology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Institute of Hematology, Coagulation Unit, Beilinson Hospital, Rabin Medical Center, Israel; Sackler School of Medicine, Tel Aviv University, Israel.


OBJECTIVE: Both inflammatory bowel diseases (IBDs) and pregnancy are established risk factors for thrombotic complications, thus IBD pregnant patients can be considered at even greater risk for thrombosis as compared to non IBD pregnant women. We aimed to evaluate the risk factors associated with this prothrombotic tendency among IBD women throughout gestation.

METHODS: Women with IBD attending a multidisciplinary clinic for the preconception,antenatal and postnatal treatment were prospectively recruited during 2017-2018. Prothrombotic tendency was assessed by thrombin generation, a global marker of the activation of the coagulation system, expressed as the endogenous thrombin potential (ETP).

RESULTS: Overall, 145 IBD women and 50 healthy control subjects were enrolled in this study. Body mass index (BMI) and gestational age were comparable between the groups. ETP level was significantly higher in women with IBD compared to control subjects in all time period (P?

CONCLUSION: As determined by thrombin generation, the procoagulant potential among IBD pregnant patients was independently associated with disease activity, BMI and extra-intestinal disease involvement.

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