Wake-up Call to Clinicians: The Impact of Sleep Dysfunction on Gastrointestinal Health and Disease

Parekh PJ1, Oldfield EC 4th1,2, Johnson DA1,2. J Clin Gastroenterol. 2017 Nov 17. doi: 10.1097/MCG.0000000000000963. [Epub ahead of print]

Author information

1 Department of Internal Medicine, Division of Gastroenterology and Hepatology, Carilion Clinic, Roanoke.

2 Eastern Virginia Medical School, Norfolk, VA.


Sleep dysfunction is an epidemic affecting a large portion of the adult population. Recent studies have linked sleep dysfunction with an upregulation of proinflammatory cytokines (eg, tumor necrosis factor-α, interleukin-1 and interleukin-6), the implications of which can have a profound impact on a variety of gastrointestinal disease. In particular, sleep dysfunction seems to accelerate disease states characterized by inflammation (eg, gastroesophageal reflux disease, irritable bowel syndrome and functional dyspepsia, chronic liver disease, inflammatory bowel disease, and colorectal cancer). This article evaluates the complex interplay between sleep dysfunction and gastrointestinal health and disease.

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