A Comprehensive Approach to Pouch Disorders

Quinn KP1, Lightner AL2, Faubion WA1, Raffals LE1. Inflamm Bowel Dis. 2018 Aug 16. doi: 10.1093/ibd/izy267. [Epub ahead of print]

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1 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

2 Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA.


Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the surgical procedure of choice for patients with medically refractory ulcerative colitis (UC) or indeterminate colitis, UC with colonic dysplasia or neoplasia, and familial adenomatous polyposis. In general, patients experience good function outcomes and quality of life with an IPAA. Although pouchitis is the most well-recognized and frequent complication after IPAA, a number of additional inflammatory, postsurgical, structural, neoplastic, and functional complications may occur, resulting in pouch dysfunction. We herein provide a comprehensive review of pouch function and an approach to diagnosis and management of pouch complications.

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