Maternal history of recurrent pregnancy loss is associated with increased risk for long-term pediatric gastrointestinal morbidity in the offspring

Lichtman Y1, Sheiner E1, Wainstock T2, Segal I3, Landau D3, Walfisch A1. Am J Reprod Immunol. 2017 Dec 15. doi: 10.1111/aji.12799. [Epub ahead of print]
Author information

1 Soroka University Medical Center, Beer Sheva, Israel.

2 Ben-Gurion University of the Negev, Beer Sheva, Israel.

3 Israel Ministry of Health, Jerusalem, Israel.


PROBLEM: Recurrent pregnancy loss (RPL) potentially involves an abnormal maternal inflammatory response. We investigated whether children of mothers with a history of RPL are at an increased risk for childhood gastrointestinal (GI) morbidity, with a specific focus on inflammatory bowel diseases (IBD).

METHOD OF STUDY: A population-based cohort analysis comparing the risk for long-term GI morbidity in children born to mothers with and without a history of RPL. Gastrointestinal (GI) morbidity included hospitalizations involving a pre-defined set of ICD-9 codes.

RESULTS: During the study period, 242 186 newborns met the inclusion criteria; 5% of which were offspring to mothers with a history of RPL. Gastrointestinal morbidity was significantly more common in the RPL group (6.6% vs 5.3%). Specifically, offspring to mothers with a history of RPL had significantly higher rates of IBD (2.1% vs 1.7%).

CONCLUSION: Maternal history of RPL is associated with an increased risk for pediatric GI morbidity in the offspring.

© Copyright 2013-2024 GI Health Foundation. All rights reserved.
This site is maintained as an educational resource for US healthcare providers only. Use of this website is governed by the GIHF terms of use and privacy statement.