Burden of illness and treatment attitudes among participants meeting Rome IV criteria for irritable bowel syndrome: A nationwide survey in the United States Neurogastroenterol Motil. 2024 Nov;36(11):e14903. doi: 10.1111/nmo.14903. Epub 2024 Sep 2. Brian E Lacy 1, Yanqing Xu 2, Douglas C A Taylor 3, Katherine J Kosch 2, Rachel Dobrescu 4, Amy Morlock 4, Robert Morlock 5, Ceciel Rooker 6 |
Author information 1Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA. 2AbbVie Inc, North Chicago, Illinois, USA. 3Former employee of Ironwood Pharmaceuticals, Boston, Massachusetts, USA. 4Acumen Health Research Institute, Ann Arbor, Michigan, USA. 5YourCareChoice, Ann Arbor, Michigan, USA. 6International Foundation for Gastrointestinal Disorders, Milwaukee, Wisconsin, USA. Abstract Background: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by abdominal pain and altered bowel habits, with patient-perceived dissatisfaction of treatment symptom control. We assessed disease burden, satisfaction with medication use, and impact on activities, in participants with IBS with constipation (IBS-C) and diarrhea (IBS-D). Methods: This study assessed data from a large, United States survey of adults querying demographics, comorbid conditions, quality of life, medication use, satisfaction with symptom control, and work productivity. Participants were grouped into the IBS-C or IBS-D cohort if they met Rome IV criteria, with controls matched 1:1 according to age, sex, race, region, and Charlson Comorbidity Index score. All data were self-reported. Key results: Nine hundred and ten participants with IBS-C and 669 with IBS-D were matched to controls. The most reported symptoms were abdominal discomfort for IBS-C and abdominal pain and abdominal discomfort for IBS-D. Among the IBS-C and IBS-D cohorts, 74.2% and 65.9%, respectively, took prescription and/or over-the-counter medication for their symptoms. Respondents were more dissatisfied than satisfied with control of their symptoms. Respondents taking prescription medication(s) with or without over-the-counter medication(s) reported better symptom control than respondents only taking over-the-counter medications (p < 0.001). There was significantly higher mean presenteeism, work productivity loss, and daily activity impairment (p < 0.001 for all) in respondents with IBS compared with controls. Conclusions and inferences: This study provides insight into respondents' experiences of IBS symptoms, including the impact on daily activity, as well as satisfaction with control of symptoms and prescription and over-the-counter medications. |
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