Abstract

Follow-up evaluation and management of anemia in inflammatory bowel disease: A study by the Italian Group for Inflammatory Bowel Diseases (IG-IBD)

Dig Liver Dis. 2024 Jan 30:S1590-8658(24)00193-2. doi: 10.1016/j.dld.2024.01.176.Online ahead of print.

 

Gaetano Bergamaschi 1Fabiana Castiglione 2Renata D'Incà 3Marco Astegiano 4Walter Fries 5Monica Milla 6Carolina Ciacci 7Fernando Rizzello 8Simone Saibeni 9Rachele Ciccocioppo 10Ambrogio Orlando 11Fabrizio Bossa 12Mariabeatrice Principi 13Piero Vernia 14Chiara Ricci 15Maria L Scribano 16Giorgia Bodini 17Dario Mazzucco 18Gabrio Bassotti 19Gabriele Riegler 20Andrea Buda 21Matteo Neri 22Flavio Caprioli 23Fabio Monica 24Aldo Manca 25Erica Villa 26Gionata Fiorino 27Nicola Aronico 28Marco V Lenti 28Caterina Mengoli 28Anna Testa 2Maurizio Vecchi 23Catherine Klersy 29Antonio Di Sabatino 30RIDART I investigators

 

RIDART I investigators: 

Giuseppe Amodeo 31Elisabetta Antonelli 32Noemi Bertetti 33Cristina Bezzio 34Michele Campigotto 35Roberta Caccaro 36Manuela De Bona 37Cristina Della Corte 34Maria G Demarzo 38Giuliano Falasco 39Rosanna Fontana 40Paolo Gionchetti 41Paola Iovino 42Federica Lepore 43Greta Lorenzon 36Veronica Marasco 44Alessandro Paolini 35Lucienne Pellegrini 45Alberto Pieraccini 46Tiziana Pinto-Vraca 47Davide Ribaldone 48Giulia Rizzuto 49Jenny Roselli 44Giovanni Santacroce 43Alessia Todeschini 50Marta Vernero 

 
     

Author information

1Medicina Generale I, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, 27100 Pavia, Italy. Electronic address: gaetanobergamaschi@gmail.com.

2Gastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, 80138 Naples, Italy.

3Inflammatory Bowel disease Unit- AO-University of Padua, 35122 Padova, Italy.

4Gastroenterology and Digestive Endoscopy Unit, "Città della Salute e della Scienza" Hospital, 10126 Torino, Italy.

5Gastroenterology and Clinical Unit for inflammatory bowel diseases, Dept. of Clinical and Experimental Medicine; University of Messina, 98122 Messina, Italy.

6Unità operativa complessa di Gastroenterologia clinica, Azienda ospedaliero universitaria Careggi- Firenze, 50134 Firenze, Italy.

7Gastroenterology and Endoscopy Unit, AOU San Giovanni di Dio e Ruggi d'Aragona and University of Salerno, 84084 Salerno, Italy.

8Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

9Gastroenterology Unit, Rho Hospital, ASST Rhodense, 20017 Rho (MI), Italy.

10Gastroenterology Unit, Department of Medicine, A.O.U.I. Policlinico G.B. Rossi & University of Verona, 37134 Verona, Italy.

11Inflammatory Bowel Disease Unit, A.O.O.R. "Villa Sofia-Cervello", 90146 Palermo Italy.

12Department of Gastroenterology and Endoscopy, Fondazione "Casa Sollievo della Sofferenza", IRCCS, 71013 San Giovanni Rotondo, Italy.

13Gastroenterology Unit (D.E.T.O.), University of Bari, 70121 Bari, Italy.

14Division of Gastroenterology, Department of Translational and Precision Medicine, "Sapienza" University of Rome and Umberto I Hospital, 00161 Rome, Italy.

15Dept of Experimental and Clinical Science, University of Brescia, Gastroenterology Unit,Spedali Civili Hospital, 25123 Brescia. Italy.

16Gastroenterology and Endoscopy Unit, Azienda Ospedaliera San Camillo-Forlanini, 00152 Rome, Italy; Villa Stuart, Multi-Speciality Clinic, 00135 Rome, Italy.

17Gastroenterology unit, Department of Internal medicine, Policlinico San Martino, Università di Genova, 16132 Genoa, Italy.

18Gastroenterology Unit, ASL TO3, 10097 Rivoli, Torino, Italy.

19Gastroenterology, Hepatology & Digestive Endoscopy Section, Department of Medicine & Surgery, University of Perugia and Perugia General Hospital, 06129 Perugia, Italy.

20Unit of Gastroenterology - Reference Center for IBD - Second University of Naples, 80138 Naples, Italy.

21Department of Gastrointestinal Oncological Surgery, Gastroenterology Unit, S. Maria del Prato Hospital, 30032 Feltre, Italy.

22Department of Medicine and Ageing Sciences and Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, 66013 Chieti, Italy.

23Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico and Università degli Studi di Milano, 20122 Milan, Italy.

24Gastroenterology and Digestive Endoscopy Unit, Cattinara Academic Hospital, 34149 Trieste, Italy.

25Department of Gastroenterology and Digestive Endoscopy, S. Croce e Carle Hospital, 12100 Cuneo, Italy.

26UC Gastroenterologia, Dipartimento di Specialità Mediche, Azienda Ospedaliera Universitaria di Modena, 41125 Modena, Italy.

27Department of Gastroenterology and Digestive Endoscopy, San Raffaele Hospital and Vita-Salute San Raffaele University, 20132 Milan, Italy; IBD Unit, San Camillo-Forlanini Hospital, 00152 Rome, Italy.

28Medicina Generale I, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, 27100 Pavia, Italy.

29Servizio di Epidemiologia Clinica & Biometria, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy.

30Medicina Generale I, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, 27100 Pavia, Italy. Electronic address: a.disabatino@smatteo.pv.it.

31Gastroenterology Unit, Department of Medicine, A.O.U.I. Policlinico G.B. Rossi & University of Verona, 37134 Verona, Italy.

32Gastroenterology, Hepatology & Digestive Endoscopy Section, Department of Medicine & Surgery, University of Perugia and Perugia General Hospital, 06129 Perugia, Italy.

33Division of Gastroenterology, Department of Translational and Precision Medicine, "Sapienza" University of Rome and Umberto I Hospital, 00161 Rome, Italy.

34Gastroenterology Unit, Rho Hospital, ASST Rhodense, 20017 Rho (MI), Italy.

35Gastroenterology and Digestive Endoscopy Unit, Cattinara Academic Hospital, 34149 Trieste, Italy.

36Inflammatory Bowel disease Unit- AO-University of Padua, 35122 Padova, Italy.

37Department of Gastrointestinal Oncological Surgery, Gastroenterology Unit, S. Maria del Prato Hospital, 30032 Feltre, Italy.

38Gastroenterology and Clinical Unit for inflammatory bowel diseases, Dept. of Clinical and Experimental Medicine; University of Messina, 98122 Messina, Italy; Gastroenterology unit, Department of Internal medicine, Policlinico San Martino, Università di Genova, 16132 Genoa, Italy.

39Gastroenterology and Endoscopy Unit, Azienda Ospedaliera San Camillo-Forlanini, 00152 Rome, Italy; Villa Stuart, Multi-Speciality Clinic, 00135 Rome, Italy.

40Department of Gastroenterology and Endoscopy, Fondazione "Casa Sollievo della Sofferenza", IRCCS, 71013 San Giovanni Rotondo, Italy.

41Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

42Gastroenterology and Endoscopy Unit, AOU San Giovanni di Dio e Ruggi d'Aragona and University of Salerno, 84084 Salerno, Italy.

43Medicina Generale I, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, 27100 Pavia, Italy.

44Unità operativa complessa di Gastroenterologia clinica, Azienda ospedaliero universitaria Careggi- Firenze, 50134 Firenze, Italy.

45Gastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, 80138 Naples, Italy.

46UO Gastroenterologia ed Endoscopia Digestiva, Ospedale San Jacopo, 51100 Pistoia, Italy.

47Gastroenterology and Clinical Unit for inflammatory bowel diseases, Dept. of Clinical and Experimental Medicine; University of Messina, 98122 Messina, Italy.

48Gastroenterology and Digestive Endoscopy Unit, "Città della Salute e della Scienza" Hospital, 10126 Torino, Italy.

49Inflammatory Bowel Disease Unit, A.O.O.R. "Villa Sofia-Cervello", 90146 Palermo Italy.

50Gastroenterology Unit (D.E.T.O.), University of Bari, 70121 Bari, Italy.

51Dept of Experimental and Clinical Science, University of Brescia, Gastroenterology Unit,Spedali Civili Hospital, 25123 Brescia. Italy.

Abstract

Background: The RIDART I study found a 13.6% prevalence of anemia in Italian patients with inflammatory bowel disease (IBD); most cases were due to iron-deficiency anemia (IDA).

Aims: To evaluate changes in hemoglobin concentration during a 24-week follow-up of anemic patients with IBD.

Methods: Follow-up laboratory and clinical data were obtained from RIDART I study patients with anemia. Factors affecting hemoglobin concentration, the impact of anemia on fatigue and quality of life (QoL), and its relationship with treatment, disease activity and disease complications were investigated.

Results: Hemoglobin was 108 g/L at baseline, increased to 121 g/L at follow-up week 12 (p < 0.001) and then stabilized until week 24, but most patients remained anemic, with IDA, throughout the study. Hemoglobin improvement was greater in patients receiving either oral or parenteral iron supplementation. Following hemoglobin normalization, anemia relapse rate during follow-up was 30%. Oral iron did not cause disease reactivation. Lower follow-up hemoglobin was associated with a higher probability of having active disease, clinical complications, increased fatigue and reduced QoL.

Conclusions: In anemic patients with IBD, anemia represents a long-lasting problem, in most cases persisting for up to 24 weeks, with high relapse rate and a negative impact on fatigue and QoL.

© Copyright 2013-2024 GI Health Foundation. All rights reserved.
This site is maintained as an educational resource for US healthcare providers only. Use of this website is governed by the GIHF terms of use and privacy statement.