Efficacy of Sacral Nerve Stimulation in Non-constipated Irritable Bowel Syndrome Patients: A Systematic Review J Gastrointestin Liver Dis. 2023 Sep 29;32(3):384-392. doi: 10.15403/jgld-4801.
Ana Maria Garcia-Cabrera 1, Fernando De la Portilla 2, Rosa María Jiménez-Rodríguez 3, Jorge Manuel Vázquez-Monchul 4, María Luisa Reyes-Díaz 5, Irene María Ramallo-Solís 6, José Pintor-Tortolero 7, Sandra Dios-Barbeito 8, Francisco Javier Padillo-Ruiz 9 |
Author information 1Virgen del Rocío University Hospital, Seville, Spain. anam.gcabrera@gmail.com. 2Virgen del Rocío University Hospital, Seville, Spain. delaportilla@ucpsevilla.es. 3Virgen del Rocío University Hospital, Seville, Spain. ros_j_r@hotmail.com. 4Virgen del Rocío University Hospital, Seville, Spain. jmvmco@hotmail.com. 5Virgen del Rocío University Hospital, Seville, Spain. milu_1983@hotmail.com. 6Virgen del Rocío University Hospital, Seville, Spain. irene.ramallo@gmail.com. 7Virgen del Rocío University Hospital, Seville, Spain. jose.pintor.tortolero@gmail.com. 8Virgen del Rocío University Hospital, Seville, Spain. sandra_dios89@hotmail.com. 9Virgen del Rocío University Hospital, Seville, Spain. javierpadilloruiz@gmail.com. Abstract Background and aims: Irritable bowel syndrome (IBS) is a prevalent disorder with a complex and heterogeneous physiopathology, including a dysregulation of gut-brain axis. Treatment for IBS is targeted to the predominant symptom and requires a multidisciplinary approach. This review aims to evaluate the efficacy and safety of sacral nerve stimulation in non-constipated IBS patients Methods: A literature search was carried out on MEDLINE, The Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science databases for all relevant articles. Quality of included papers was assessed using standardized guidelines Results: Of 129 initial citations, 7 articles met our predefined inclusion criteria, including five randomized trials, a pilot study and a descriptive follow-up study. Five of 7 studies reported a positive effect of sacral nerve stimulation on symptoms and quality of life improvement in non-constipated IBS patients. No study reported serious adverse events. Conclusions: Despite initial promising results of sacral nerve stimulation in non-constipated IBS patients, studies with larger sample sizes and longer follow-up are required. |
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