The Interface between Inflammatory Bowel Disease, Neuroinflammation, and Neurological Disorders

Semin Neurol. 2023 Aug;43(4):572-582. doi: 10.1055/s-0043-1771467.Epub 2023 Aug 10.


Grace E Hey 1Vinata Vedam-Mai 1Matthew Beke 1 2Manuel Amaris 3Adolfo Ramirez-Zamora 1


Author information

1Department of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida.

2Department of Food Science and Human Nutrition, University of Florida, Gainesville, Florida.

3Department of Gastroenterology, University of Florida, Gainesville, Florida.


Inflammatory Bowel Disease (IBD) is a complex, chronic inflammatory condition affecting the gastrointestinal tract. IBD has been associated with a variety of neurologic manifestations including peripheral nerve involvement, increased risk of thrombotic, demyelinating and events. Furthermore, an evolving association between IBD and neurodegenerative disorders has been recognized, and early data suggests an increased risk of these disorders in patients diagnosed with IBD. The relationship between intestinal inflammatory disease and neuroinflammation is complex, but the bidirectional interaction between the brain-gut-microbiome axis is likely to play an important role in the pathogenesis of these disorders. Identification of common mechanisms and pathways will be key to developing potential therapies. In this review, we discuss the evolving interface between IBD and neurological conditions, with a focus on clinical, mechanistic, and potentially therapeutic implications.

© Copyright 2013-2024 GI Health Foundation. All rights reserved.
This site is maintained as an educational resource for US healthcare providers only. Use of this website is governed by the GIHF terms of use and privacy statement.