Dig Liver Dis. 2023 May;55(5):580-586. doi: 10.1016/j.dld.2022.08.017.Epub 2022 Sep 1.

Giacomo Fuschillo ¹, Valerio Celentano ², Matteo Rottoli ³, Guido Sciaudone ¹, Antonietta Gerarda Gravina ⁴, Raffaele Pellegrino ⁴, Raffaele Marfella ¹, Marco Romano ⁴, Francesco Selvaggi ¹, Gianluca Pellino ⁵

Author information

¹Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.

²Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom; Department of Surgery and Cancer. Imperial College, London, United Kingdom.

³Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero Universitaria di Bologna, Italy; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.

⁴Department of Precision Medicine, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.

⁵Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy; Colorectal Surgery, Vall d'Hebron University Hospital, Barcelona, Spain. Electronic address: gianluca.pellino@unicampania.it.

Abstract

Background: Diabetes Mellitus (DM) may occur in IBD and influence the disease progression.

Aim: To compare disease course and treatment outcomes in IBD patients with and without DM.

Methods: This is a systematic review with meta-analysis comparing patients with IBD plus DM with patients with IBD only.

Primary endpoints: need for surgery, IBD-related complications, hospitalizations, sepsis, mortality. Quality of life and costs were assessed.

Results: Five studies with 71,216 patients (49.1% with DM) were included. Risk for IBD-related complications (OR=1.12, I² 98% p = 0.77), mortality (OR=1.52, I² 98% p = 0.37) and IBD-related surgery (OR=1.20, I² 81% p = 0.26) did not differ. Risk of IBD-related hospitalizations (OR=2.52, I²0% p < 0.00001) and sepsis (OR=1.56, I² 88% p = 0.0003) was higher in the IBD+DM group. Risk of pneumonia and urinary tract infections was higher in the IBD+DM group (OR=1.72 and OR=1.93), while risk of C. Difficile infection did not differ (OR=1.22 I² 88% p = 0.37). Mean Short Inflammatory Bowel Disease Questionnaire score was lower in the IBD+DM group (38.9 vs. 47, p = 0.03). Mean health care costs per year were $10,598.2 vs $3747.3 (p < 0.001).

Conclusion: DM might negatively affect the course of IBD by increasing the risk of hospitalization and infections, but not IBD-related complications and mortality.