Curr Opin Gastroenterol. 2023 Jul 1;39(4):274-286.doi: 10.1097/MOG.0000000000000953. Epub 2023 May 26.

Jeffrey A Berinstein ¹, Daniel Aintabi ², Peter D R Higgins ¹

Author information

¹Division of Gastroenterology and Hepatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor.

²Department of Medicine, Trinity Health Ann Arbor Hospital, Ypsilanti, Michigan, USA

Abstract

Purpose of review: The management of hospitalized patients with inflammatory bowel disease (IBD) is complex. Despite considerable therapeutic advancements in outpatient ulcerative colitis and Crohn's disease management, the in-hospital management continues to lag with suboptimal outcomes. The purpose of this review is to provide a brief overview of our approach to managing patients hospitalized with acute severe ulcerative colitis (ASUC) and Crohn's disease-related complications, followed by a summary of emerging evidence for new management approaches.

Recent findings: ASUC has seen the emergence of well validated prognostic models for colectomy as well as the development of novel treatment strategies such as accelerated infliximab dosing, Janus kinase inhibitor therapy, and sequential therapy, yet the rate of colectomy for steroid-refractory ASUC has not meaningfully improved. Crohn's disease has seen the development of better diagnostic tools, early Crohn's disease-related complication stratification and identification, as well as better surgical techniques, yet the rates of hospitalization and development of Crohn's disease-related complications remain high.

Summary: Significant progress has been made in the in-hospital IBD management; however, both the management of ASUC and hospitalized Crohn's disease remain a challenge with suboptimal outcomes. Critical knowledge gaps still exist, and dedicated studies in hospitalized patients with IBD are needed to address them.