Inflammatory Bowel Disease and Customized Nutritional Intervention Focusing on Gut Microbiome Balance

Nutrients. 2022 Oct 3;14(19):4117. doi: 10.3390/nu14194117.


Camilla Fiorindi 1Edda Russo 2Lucrezia Balocchini 1Amedeo Amedei 2Francesco Giudici 2


Author information

1Department of Health Science, AOUC Careggi, 50134 Florence, Italy.

2Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.


Inflammatory bowel disease (IBD) represents a chronic relapsing-remitting condition affecting the gastrointestinal system. The specific triggering IBD elements remain unknown: genetic variability, environmental factors, and alterations in the host immune system seem to be involved. An unbalanced diet and subsequent gut dysbiosis are risk factors, too. This review focuses on the description of the impact of pro- and anti-inflammatory food components on IBD, the role of different selected regimes (such as Crohn's Disease Exclusion Diet, Immunoglobulin Exclusion Diet, Specific Carbohydrate Diet, LOFFLEX Diet, Low FODMAPs Diet, Mediterranean Diet) in the IBD management, and their effects on the gut microbiota (GM) composition and balance. The purpose is to investigate the potential positive action on IBD inflammation, which is associated with the exclusion or addition of certain foods or nutrients, to more consciously customize the nutritional intervention, taking also into account GM fluctuations during both disease flare-up and remission.



© Copyright 2013-2024 GI Health Foundation. All rights reserved.
This site is maintained as an educational resource for US healthcare providers only. Use of this website is governed by the GIHF terms of use and privacy statement.