Systematic review: the role of psychological stress in inflammatory bowel disease

Aliment Pharmacol Ther. 2022 Oct;56(8):1235-1249. doi: 10.1111/apt.17202.Epub 2022 Sep 8.


Jacqueline Black 1Louise Sweeney 1 2Yuhan Yuan 1Harinder Singh 3Christine Norton 1Wladyslawa Czuber-Dochan 1


Author information

1King's College London, Florence Nightingale Faculty of Nursing, Midwifery, and Palliative Care, James Clerk Maxwell Building, London, UK.

2King's College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK.

3Study Advisory Group, London, UK.


Background: Psychological stress is a possible factor in the disease course and poor psychosocial outcomes in inflammatory bowel disease (IBD). Understanding the exact relationship between stress and health has been hampered by methodological issues and how stress has been defined and measured.

Aims: To explore the association between stress and disease outcomes, investigate the impact of stress on psychosocial outcomes, and evaluate the efficacy of interventions in reducing stress for people with IBD METHODS: We performed a systematic review, searching Medline, CINAHL, Embase and PsycInfo databases on 21 January 2021. We included prospective studies that recruited people with IBD who were aged 16 or over and that measured psychological stress or distress. Analyses included Critical Appraisal Skills Programme quality assessments of included studies and narrative analyses against each research question.

Results: We reviewed 38 studies with 4757 people with IBD, and included 23 observational and 15 interventional studies using 36 different instruments to measure stress. Perceived stress was the most frequently studied concept and preceded IBD exacerbation. Only three studies examined the relationship between stress and psychosocial factors. Cognitive behavioural interventions may reduce stress and other interventions with disease-specific stress, but more studies are needed where groups have comparable baseline characteristics and potential harms are considered alongside benefits.

Conclusion: Psychological stress appears to precede IBD exacerbation, although what role it plays in psychosocial outcomes and how it is best managed is unclear. Further research needs to examine the differential effects of stress on disease subtypes and IBD in flare and remission.



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