Irritable bowel syndrome with food-related symptoms: Future directions in the clinical management

United European Gastroenterol J. 2022 Jul;10(6):594-600. doi: 10.1002/ueg2.12265.Epub 2022 Jun 21.


Chloé Melchior 1 2 3Joost Algera 1Esther Colomier 1 4Hans Törnblom 1Magnus Simrén 1 5


Author information

1Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

2INSERM UMR 1073, Institute for Research and Innovation in Biomedicine, Normandy University, Rouen, France.

3Rouen University Hospital, Gastroenterology Department and INSERM CIC-CRB 1404, Rouen, France.

4Department of Translational Research for Gastrointestinal Disorders, University Hospital KU Leuven, University of Leuven, Leuven, Belgium.

5Centre for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina, USA.


The majority of patients with irritable bowel syndrome (IBS) experiences food-related symptoms, which are associated with high symptom burden, reduced quality of life, increased healthcare consumption and reduced intake of certain nutrients. In this review we aimed to describe a clinically useful approach for physicians, by presenting the latest progress in knowledge and its translation to management in IBS patients with food-related symptoms, as well as the underlying mechanisms involved. The research tools currently available that can be used in the future for a better characterization of this subgroup of patients are also discussed. Working towards this approach could lead to a more individualised work-up and management of IBS patients with food-related symptoms.


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