Dig Dis Sci. 2022 Jun;67(6):2067-2073. doi: 10.1007/s10620-021-07040-z. Epub 2021 May 12.

Bénédicte Caron ¹, Elise Neuville ¹, Laurent Peyrin-Biroulet ²

Author information

¹Department of Gastroenterology and Inserm NGERE U1256, Nancy University Hospital, University of Lorraine, 1 Allée du Morvan, 54511, Vandoeuvre-lès-Nancy, France.

²Department of Gastroenterology and Inserm NGERE U1256, Nancy University Hospital, University of Lorraine, 1 Allée du Morvan, 54511, Vandoeuvre-lès-Nancy, France. peyrinbiroulet@gmail.com.

Abstract

Background: Vaccination against COVID-19 is a major public health challenge, including the community of patients with inflammatory bowel disease. Vaccination coverage is suboptimal in inflammatory bowel disease population. It is of paramount importance to ensure an effective and rapid vaccination program with the adherence of the largest number of well-informed patients.

Aims: We assessed the acceptance of COVID-19 vaccination among inflammatory bowel disease patients.

Methods: We performed a survey as part of routine practice, between January 8th and February 22nd, 2021. All consecutive adult patients followed at Nancy University Hospital for inflammatory bowel disease were included. Patients completed a self-administered, structured, paper-based questionnaire. Demographic data, medical history, knowledge, and perceptions of COVID-19 vaccination were collected.

Results: Among the 104 patients who responded to the survey, 57 patients (54.8%) had intent to receive the COVID-19 vaccine. Vaccine efficacy, social responsibility, herd immunity, and desire to return to normal life were associated with self-reported willingness to receive a vaccine (20.2%, 20.2%, 11.5%, and 15.4%, respectively). Unknown long-term safety, risk of adverse reaction to vaccine and concern that the vaccine is being developed too quickly were the most commonly reported reasons for non-uptake (27.9%, 15.4%, and 12.5%, respectively).

Conclusion: Half of the patients with inflammatory bowel disease would like to be vaccinated against SARS-CoV-2. This rate is similar to that reported in the French general population. Despite some concerns, patients with inflammatory bowel disease understood the necessity to be vaccinated against COVID-19.