Ocular Manifestations of Inflammatory Bowel Disease

Inflamm Bowel Dis. 2021 Oct 20;27(11):1832-1838.doi: 10.1093/ibd/izaa359.

Janaki Shah 1, Aaditya Shah 2, Lynn Hassman 2, Alexandra Gutierrez 1


Author information

  • 1Department of Internal Medicine, Washington University in St. Louis, St. Louis, Missouri, USA.
  • 2Department of Ophthalmology, Washington University in St. Louis, St. Louis, MO, USA.


Inflammatory bowel disease (IBD) is characterized by intestinal inflammation; however, it is also known to have extraintestinal manifestations. Ocular manifestations of IBD include keratopathy, episcleritis, scleritis, and uveitis and are among the most common extraintestinal manifestations. These diseases can lead to significant ocular morbidity if unrecognized and left untreated. A review of the literature was performed on PubMed and is summarized and critically appraised in this article with the aim being to describe the varying ocular manifestations of IBD and outlining their treatments. Ultimately, a framework is provided to investigate ocular symptoms in patients with IBD. An ocular review of systems is also provided as a tool to equip gastroenterologists and internal medicine physicians to be able to recognize and triage ocular complaints appropriately.

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