Abstract

Revisiting the Association Between Inflammatory Bowel Disease and Parkinson's Disease

Inflamm Bowel Dis. 2021 Jul 14;izab175. doi: 10.1093/ibd/izab175. Online ahead of print.

Matthew D Coates 1Djibril M Ba 2 3Guodong Liu 2 3Shannon Dalessio 1Douglas L Leslie 2 3Xuemei Huang 4

 
     

Author information

  • 1Department of Medicine, Division of Gastroenterology and Hepatology, Penn State University College of Medicine, Hershey, PA, USA.
  • 2Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA, USA.
  • 3Center for Applied Studies in Health Economics (CASHE), Penn State College of Medicine, Hershey, PA, USA.
  • 4Department of Neurology, Penn State University College of Medicine, Hershey, PA, USA.

Abstract

Background: Several studies have reported an association between inflammatory bowel disease (IBD) and Parkinson's disease (PD). The aim of this study is to re-evaluate for an association between IBD and PD while controlling for potential socioeconomic and environmental confounders.

Methods: We performed a retrospective cohort study using the Truven Health Marketscan database between January 1, 2005, and December 31, 2014. Individuals with IBD and household age-matched controls were identified. Adjusted hazard ratios (HRs) were calculated for the development of incident PD, adjusting for age, sex, residence type, US region, comorbidities, and behavior.

Results: In all, 154 051 subjects with IBD and an equal number of controls were identified. During a mean (SD) follow-up of 3.8 (2.2) years, 132 incident PD cases were identified. There was no significant association between IBD and PD (adjusted HR, 1.01; 0.72-1.42) when adjusting for the confounders previously mentioned.

Conclusions: We found no statistically significant association between these disorders. It is possible that previous associations identified between these disorders were confounded by environmental and socioeconomic factors.

© Copyright 2013-2022 GI Health Foundation. All rights reserved.
This site is maintained as an educational resource for US healthcare providers only. Use of this website is governed by the GIHF terms of use and privacy statement.