Abstract

Abdominal Pain After Pediatric Inflammatory Bowel Disease Diagnosis: Results From the ImproveCareNow Network

J Pediatr Gastroenterol Nutr. 2020 Dec;71(6):749-754. doi: 10.1097/MPG.0000000000002933.

Lexa K Murphy 1, David L Suskind 2, Pingping Qu 1, Chuan Zhou 1 3, Kaltrina Gashi 4, Joy S Kawamura 5, Tonya M Palermo 1 6, ImproveCareNow Pediatric IBD Learning Health System, as stipulated by ICN

 
     

Author information

  • 1Center for Child Health, Behavior and Development, Seattle Children's Research Institute.
  • 2Department of Pediatrics, Division of Gastroenterology.
  • 3Department of Pediatrics, Division of General Pediatrics, University of Washington.
  • 4School of Medicine, University of Saarland.
  • 5Department of Psychiatry, University of Washington.
  • 6Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA.

Abstract

Objectives: Although abdominal pain is a hallmark symptom of pediatric inflammatory bowel disease (IBD), limited research has examined pain during the first year after diagnosis. The purpose of the present study is to examine prevalence, predictors, and impact of abdominal pain during the 12 months after pediatric IBD diagnosis using data from the ImproveCareNow (ICN) Network.

Patients and methods: Participants consisted of 13,875 youth (age 8-18 years, 44% female, 81% Caucasian) with IBD (65% Crohn's disease; 27% ulcerative colitis, 8% indeterminate colitis) enrolled in the ICN Network with data from clinic visits during the first year after diagnosis (1-22 visits; mean = 3.7). Multivariable mixed effects logistic regression models were conducted to analyze the presence versus the absence of abdominal pain, activity limitations, and decrements in well-being.

Results: The percentage of youth reporting abdominal pain decreased significantly during the first year after diagnosis and yet a sizeable group reported continued pain at 12 months (55.9% at diagnosis; 34.0% at 12 months). Multivariable analyses revealed that greater time since diagnosis (odds ratio [OR] = 0.98, P < 0.001), higher disease severity (OR = 11.84, P < 0.001), presence of psychosocial risk factors (OR = 2.33, P = 0.036), and female sex (OR = 1.90, P < 0.010) were significant correlates of continuing abdominal pain. Abdominal pain was significantly associated with decrements in well-being (OR = 5.11, P < 0.001) as well as limitations in activity (OR = 9.31, P < 0.001), over and above the influence of disease severity.

Conclusions: Abdominal pain is prevalent and impactful, even when controlling for disease activity, during the first year after pediatric IBD diagnosis. Results from the present study can inform screening and tailored pain management intervention efforts in pediatric IBD.

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