Impact of BMGIM Music Therapy on Emotional State in Patients with Inflammatory Bowel Disease: A Randomized Controlled Trial

J Clin Med. 2021 Apr 9;10(8):1591. doi: 10.3390/jcm10081591.

Vicente Alejandro March-Luján 1, Vicente Prado-Gascó 2, José María Huguet 3, Xavier Cortés 4 5, José María Paredes Arquiola 6, María Capilla-Igual 7, María Josefa-Rodríguez-Morales 4, Ana Monzó-Gallego 3, José Luis Platero Armero 8, José Enrique de la Rubia Ortí 8


Author information

  • 1Department of Teaching and Learning of Physical, Plastic and Musical Education, Catholic University San Vicente Martir, 46110 Valencia, Spain.
  • 2Department of Social Psychology, University of Valencia, 46010 Valencia, Spain.
  • 3Digestive Disease Department, General University Hospital of Valencia, 46014 Valencia, Spain.
  • 4Digestive Disease Department, Hospital of Sagunto, 46520 Valencia, Spain.
  • 5Universidad Cardenal Herrera-CEU, CEU Universities, 46113 Valencia, Spain.
  • 6Digestive Disease Department, Peset University Hospital of Valencia, 46017 Valencia, Spain.
  • 7Research Foundation of the General Hospital of Valencia, 46014 Valencia, Spain.
  • 8Department of Nursing, Catholic University San Vicente Martir, 46001 Valencia, Spain.


Background: Patients with inflammatory bowel disease (IBD) have a high prevalence of emotional disturbances which worsen the symptoms of the disease. As a therapeutic alternative that is part of a comprehensive care alongside medication, the Bonny Method of Guided Imagery and Music (BMGIM) music-assisted therapy has achieved promising emotional improvements in patients with chronic diseases. The objective of the study was to determine the impact of a treatment based on a BMGIM group adaptation on patients with inflammatory bowel disease (IBD) and their emotional state, therefore analyzing state of mind, quality of life, anxiety, depression, immunocompetence as a marker of well-being, and levels of acute and chronic stress.

Methods: Longitudinal, prospective, quantitative, and experimental study including 43 patients with IBD divided into an intervention group (22 patients), who received eight sessions over eight weeks, and a control group (21 patients). A saliva sample was taken from each patient before and after each session in order to determine cortisol and IgA levels. Similarly, a hair sample was taken before the first and after the last session to determine the cumulative cortisol level. All molecules were quantified using the ELISA immunoassay technique. In addition, patients completed several emotional state questionnaires: HADS, MOOD, and CCVEII.

Results: An improvement was observed in the following states of mind: sadness, fear, anger, and depression. No significant effect was observed in state of mind in terms of happiness or anxiety, in the levels of cortisol in hair, and in patients' perceived quality of life. A reduction in cortisol was observed in saliva, although this did not significantly affect the IgA titer.

Conclusions: BMGIM seems to improve the emotional state of patients with IBD.

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