Abstract

Redundancy in the International Anorectal Physiology Working Group Manometry Protocol: A Diagnostic Accuracy Study in Fecal Incontinence

Dig Dis Sci. 2021 May 3. doi: 10.1007/s10620-021-06994-4. Online ahead of print.

Daphne Ang 1 2Paul Vollebregt 1 3Emma V Carrington 1 4Charles H Knowles 1 3S Mark Scott 5

 
     

Author information

  • 1The Wingate Institute of Neurogastroenterology, Queen Mary University of London, 26 Ashfield Street, London, E1 2AJ, UK.
  • 2Department of Gastroenterology, Changi General Hospital, 2 Simei Street 3, Singapore, 529889, Singapore.
  • 3The National Centre for Bowel Research and Surgical Innovation, 2 Newark Street, London, E1 2AT, UK.
  • 4Department of Surgery and Cancer, St Mary's Hospital, Imperial College London, Praed Street, London, W2 1NY, UK.
  • 5The Wingate Institute of Neurogastroenterology, Queen Mary University of London, 26 Ashfield Street, London, E1 2AJ, UK. m.scott@qmul.ac.uk.

Abstract

Background: Anorectal manometry (ARM) is essential for identifying sphincteric dysfunction. The International Anorectal Physiology Working Group (IAPWG) protocol and London Classification provide a standardized format for performing and interpreting ARM. However, there is scant evidence to support timing and number of constituent maneuvers.

Aims: To assess the impact of protocol modification on diagnostic accuracy in patients with fecal incontinence.

Methods: Retrospective analysis of high-resolution ARM recordings from consecutive patients based on the current IAPWG protocol and modifications thereof: (1) baseline rest period (60 vs. 30 vs. 10 s); (2) number of abnormal short squeezes (SS) out of 3 (SS1/SS2/SS3) based on maximal incremental squeeze pressures over 5 s; (3) resting anal pressures (reflecting recovery) at 25-30 versus 15-20 s after SS1.

Results: One hundred patients (86 F, median age 55 [IQR: 39-65]; median St. Mark's incontinence score 14 [10-17]) were studied. 26% and 8% had anal hypotonia and hypertonia, respectively. Compared with 60-s resting pressure, measurements had perfect correlation (κ = 1.0) over 30 s, and substantial correlation (κ = 0.85) over 10 s. After SS1, SS2, and SS3, 43%, 49%, and 46% had anal hypocontractility, respectively. Correlation was substantial between SS1 and SS2 (κ = 0.799) and almost perfect between SS2 and SS3 (κ = 0.9). Compared to resting pressure of 5 s before SS1, pressure recordings at 25-30 and 15-20 s after SS1 were significantly correlated.

Conclusions: A 30-s resting anal pressure, analysis of 2 short-squeezes with a 20-s between-maneuver recovery optimizes study duration without compromising diagnostic accuracy. These findings indicate the IAPWG protocol has redundancy.

© Copyright 2013-2021 GI Health Foundation. All rights reserved.
This site is maintained as an educational resource for US healthcare providers only. Use of this website is governed by the GIHF terms of use and privacy statement.