Abstract

The Utility of IgA-Based Serologic Markers in Diagnosing Celiac Disease in Children 24 Months of Age or Younger

J Pediatr. 2020 Sep;224:158-161.e2. doi: 10.1016/j.jpeds.2020.04.009.Epub 2020 Jun 24.

Muhammad Rehan Khan 1, Jocelyn A Silvester 2, Brandon Sparks 3, Zackary Hintze 2, Tracy Ediger 3, Joseph J Larson 4, Ivor Hill 3, Imad Absah 5

 
     

Author information

  • 1Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Division of Pediatric Gastroenterology & Hepatology, Rochester, MN. Electronic address: khan.muhammad1@mayo.edu.
  • 2Department of Pediatrics, Harvard Celiac Research Program, Boston Children's Hospital, Boston, MA.
  • 3Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH.
  • 4Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
  • 5Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Division of Pediatric Gastroenterology & Hepatology, Rochester, MN.

Abstract

Current screening guidelines in North America for celiac disease recommend additional IgG based testing for younger children. Our multicenter retrospective study showed that the anti-tissue transglutaminase IgA antibody test should be the recommended initial test in all children, including those ≤24 months of age.

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