Trends in paediatric inflammatory bowel disease-attributable direct costs: a population-based analysis

Aliment Pharmacol Ther. 2021 Apr 9. doi: 10.1111/apt.16358. Online ahead of print.

Wael El-Matary 1 2, Zoann Nugent 2 3, Julia Witt 4, Charles N Bernstein 2 3


Author information

  • 1Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
  • 2IBD Clinical and Research Center, University of Manitoba, Winnipeg, MB, Canada.
  • 3Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
  • 4Department of Economics, University of Manitoba, Winnipeg, MB, Canada.


Background: In addition to its morbidities, inflammatory bowel disease (IBD) has a major financial burden on patients and healthcare systems. However, there is a paucity of evidence on IBD-attributable costs in children.

Aims: To determine the trends of IBD-attributable direct costs over time using a population-based analysis.

Methods: Data were extracted from Manitoba Health Provider Claims and other population registry datasets from 1995 to 2017. Children with IBD were matched by age, sex and location with children without IBD. IBD-attributable direct costs were calculated using utilization counts from the administrative data and cost estimates from different sources. Inpatient hospitalisation and outpatient procedure costs were estimated using the resource intensity weight (RIW) that is attached to each record in the data. Costs were expressed in Canadian dollars.

Results: We included 733 (428 with Crohn's disease) prevalent cases who were diagnosed with IBD before the age of 18 years and were followed for 2450 person-years. A matched control group of 6763 persons who were followed for 21 558 person-years was included. The median annual costs of physician services billed per patient increased from $381 (IQR 215-1064) in 1995 to $936 (IQR 579-1932) in 2017 (P < 0.001). The annual medication costs per patient increased from a median of $270 in 1995 to $7944 in 2017 (P < 0.0001). The median annual direct cost per patient was $1810 in 2004 as compared to $14 791 (P < 0.0001) in 2017.

Conclusions: Over two decades, there was a significant increase in the paediatric IBD-attributable direct costs mainly driven by medication costs.

© Copyright 2013-2021 GI Health Foundation. All rights reserved.
This site is maintained as an educational resource for US healthcare providers only. Use of this website is governed by the GIHF terms of use and privacy statement.