Brian Lacy, MD
Mayo Clinic
Jacksonville, FL

Dr. Brian E. Lacy is a board certified gastroenterologist who focuses his research and clinical interests on disorders of gastrointestinal motility. Dr. Lacy's areas of expertise include gastroesophageal reflux disease, dysphagia, achalasia, dyspepsia, gastroparesis, irritable bowel syndrome, constipation, intestinal pseudo-obstruction and visceral pain. Dr. Lacy is the author of over 165 peer-reviewed articles on gastrointestinal motility disorders and functional bowel disorders, has written and/or edited 6 books on gastrointestinal motility disorders and functional bowel disorders, and has written multiple text book chapters. Dr. Lacy is the current co-Editor in Chief of the American Journal of Gastroenterology. He is the former Editor in Chief of Clinical and Translational Gastroenterology. Dr. Lacy was the co-Chairman for the Rome IV Committee on Functional Bowel Disorders.

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 Antidepressant Therapy for Functional Dyspepsia

We propose to investigate whether antidepressant medications are efficacious in functional dyspepsia. The prescription of antidepressants to treat functional dyspepsia is based on three propositions. First, antidepressants could reduce the severity of co-morbid psychological symptoms, especially anxiety and depression. Second, antidepressants have central analgesic actions. Thirdly, antidepressants have been shown to have local pharmacological actions on the gut, and may specifically alter gastric emptying and fundic relaxation based on preliminary data, but the relevance of such pertubations to treatment outcome is not established.

Estimated Enrollment: 400
Study Start Date: October 2006
Estimated Study Completion Date: December 2011
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)

 Multicenter Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray in Women With Diabetic Gastroparesis

The purpose of this study is provide confirmation of the safety and efficacy of Metoclopramide Nasal Spray compared to placebo in reducing the symptoms of diabetic gastroparesis in adult women.

Estimated Enrollment: 200
Study Start Date: April 2014
Estimated Primary Completion Date: July 2015 (Final data collection date for primary outcome measure)

 Multicenter Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray in Men With Diabetic Gastroparesis

The purpose of this study is evaluate the safety and efficacy of Metoclopramide Nasal Spray compared to placebo in reducing the symptoms of diabetic gastroparesis in adult men.

Estimated Enrollment: 150
Study Start Date: April 2014
Estimated Primary Completion Date: July 2015 (Final data collection date for primary outcome measure)

 Study of Promethazine for Treatment of Diabetic Gastroparesis

Adult diabetic patients (ages 18-65) with gastric emptying scintigraphy-confirmed delayed gastric emptying will be recruited to participate in the study. Using double-blinded methodology, study participants will be randomly assigned to one of two treatment arms: promethazine 12.5 mg three times daily for 28 days or placebo three times daily for 28 days. The primary outcome will be the change in gastroparesis symptom severity, as measured by the Gastroparesis Cardinal Symptom Index (GCSI) at four weeks compared to baseline. Participants will be seen for a clinic evaluation at weeks 0, 2 and 4, during which symptom scores, adverse events and treatment compliance will be assessed. It is hypothesized promethazine treatment will be superior to placebo in improving symptoms of gastroparesis.

Estimated Enrollment: 24
Study Start Date: July 2014
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)

    Webcasts

    GHAPP Conference: Optimizing the Management of SIBO/SIFO

    Nicole Martinez de Andino, RD, APRN

    Didactic Lecture

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    GHAPP Conference: Current Perspectives on Food Intolerances

    Kate Scarlata, RDN, LDN

    Didactic Lecture

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    GHAPP Conference: IBS Applying New Advances into Practic

    Richard Davis, PA-C ; Amy Kassebaum, PA-C, RD, MMS

    Didactic Lecture

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    Xpert Perspectives on IBS from DDW 2018 in Washington, DC

    Mark Pimentel, MD; William D. Chey, MD;

    Didactic Lecture

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    The Role of the Microbiome in Health and Disease

    Mark Pimentel, MD; Janelle C. Arthur, PhD; Mark S. Riddle, MD, DrPH; Gary D. Wu, MD

    Didactic Lecture

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    Holistic Approach to Diagnosis and Management of Irritable Bowel Syndrome

    Amy Kassebaum, PA-C

    Didactic Lecture

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    Opioid Induced and Exacerbated Constipation Importance, Definitions and Rationale for a Change in Nomenclature

    Amy Kassebaum, PA-C

    Didactic Lecture

    view details >

    Small Intestinal Bacterial (SIBO) and Fungal Overgrowth (SIFO)

    Nicole Martinez de Andino, RD, APRN

    Didactic Lecture

    view details >

    Behavioral Medicine for Digestive Health

    Sarah Quinton, PsyD

    Didactic Lecture

    view details >

    Trial By Jury

    Brooks Cash, MD; William D. Chey, MD; Anthony Lembo, MD; Baha Moshiree, MD; Mark Pimentel, MD

    Didactic Lecture

    view details >

    IBS Prime

    Brooks Cash, MD; Philip Schoenfeld, MD;

    Didactic Lecture

    view details >

    Xpert Perspectives on IBS from ACG/WCOG in Orlando

    William D. Chey, MD; Brian E. Lacy, MD; Mark Pimentel, MD

    Didactic Lecture

    view details >

    Xpert Perspectives on OIC from DDW 2017 in Chicago, IL

    William D. Chey, MD

    Didactic Lecture

    view details >

    Negative Effects of Opioids on the Gastrointestinal Tract and The Development of Newer Therapeutics To Overcome Them

    Darren M. Brenner, MD

    Didactic Lecture

    view details >

    Optimizing Management of IBS-C and CIC

    Nicholas J. Talley, MD (chair), Darren M. Brenner, MD, William D. Chey, MD, Philip S. Schoenfeld, MD

    Didactic Lecture

    view details >

    Improving Patient Outcomes in IBS-D: New Evidence on Epidemiology, Pharmacology, and Mgmt

    Lin Chang, MD (chair), William D. Chey, MD, FACG, AGAF, FACP, RFF, Mark Pimentel, MD, FRCP(C), Philip S. Schoenfeld, MD, MSEd, MSc (Epi)

    Didactic Lecture

    view details >

    Beyond Gut Instincts: Applying the latest IBS advances to practice

    William D. Chey, MD, Stanley A Cohen, MD, Nicholas Talley, MD, Mark Pimentel, MD, Philip S. Schoenfeld, MD

    Didactic Lecture

    view details >

    Functional dyspepsia: A new disease model

    Nick Talley, MD

    Didactic Lecture

    view details >

    Integrating Novel Diagnostic Strategies into Practice: Key Points

    Stanley Cohen, MD

    Didactic Lecture

    view details >

    Novel Strategies for IBS-C

    Mark Pimentel, MD

    Didactic Lecture

    view details >

    Management of Severe Constipation: Dysnnergic Defecation and OIC

    Philip Schoenfeld, MD

    Didactic Lecture

    view details >

    Which Diet is Right for IBS?

    William Chey, MD

    Didactic Lecture

    view details >

    Emerging Medical Management Options for IBS-D

    William Chey, MD

    Didactic Lecture

    view details >

    Overview of IBS-C Therapies

    Christine Frissora, MD

    Didactic Lecture

    view details >

    A Primer on the Diagnosis and Management of Functional Dyspepsia

    Brian Lacy, MD

    Didactic Lecture

    view details >

    Distinguishing Celiac Disease, Non-Gluten Sensitivity and IBS

    Lucinda Harris, MD

    Didactic Lecture

    view details >

    Understanding and Managing Gastroparesis

    Linda Nguyen, MD

    Didactic Lecture

    view details >

    Opioid-Induced Bowel Dysfunction

    Darren Brenner, MD

    Didactic Lecture

    view details >

    Xpert Perspectives: New Insights into the Recognition and Management of FGIMDs 2015

    Brooks Cash, MD, William Chey, MD, Mark Pimentel, MD

    Didactic Lecture

    view details >

    Gi News Tonight: Case Discussions on Functional GI and Motility Disorders

    Lawrence Schiller, MD, Lin Chang, MD, Mark Pimentel, MD, Philip Schoenfeld, MD

    Didactic Lecture

    view details >

    eMonograph

    Understanding and Managing IBS and CIC in the primary care setting

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    An Evidence-Based Approach to IBS and CIC: Applying New Advances to Daily Practice

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    Advances in IBS

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    IBS News Tonight

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    Gastroparesis: Diagnosis and Management

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    Managing the Gastrointestinal Effects of Opioids

    view details >

    Implementing Effective Patient Communication Skills in IBS

    view details >

    Webcasts

    GHAPP Conference: Optimizing the Management of SIBO/SIFO

    Nicole Martinez de Andino, RD, APRN

    Didactic Lecture

    view details >

    GHAPP Conference: Current Perspectives on Food Intolerances

    Kate Scarlata, RDN, LDN

    Didactic Lecture

    view details >

    GHAPP Conference: IBS Applying New Advances into Practic

    Richard Davis, PA-C ; Amy Kassebaum, PA-C, RD, MMS

    Didactic Lecture

    view details >

    Xpert Perspectives on IBS from DDW 2018 in Washington, DC

    Mark Pimentel, MD; William D. Chey, MD;

    Didactic Lecture

    view details >

    The Role of the Microbiome in Health and Disease

    Mark Pimentel, MD; Janelle C. Arthur, PhD; Mark S. Riddle, MD, DrPH; Gary D. Wu, MD

    Didactic Lecture

    view details >

    Holistic Approach to Diagnosis and Management of Irritable Bowel Syndrome

    Amy Kassebaum, PA-C

    Didactic Lecture

    view details >

    Opioid Induced and Exacerbated Constipation Importance, Definitions and Rationale for a Change in Nomenclature

    Amy Kassebaum, PA-C

    Didactic Lecture

    view details >

    Small Intestinal Bacterial (SIBO) and Fungal Overgrowth (SIFO)

    Nicole Martinez de Andino, RD, APRN

    Didactic Lecture

    view details >

    Behavioral Medicine for Digestive Health

    Sarah Quinton, PsyD

    Didactic Lecture

    view details >

    Trial By Jury

    Brooks Cash, MD; William D. Chey, MD; Anthony Lembo, MD; Baha Moshiree, MD; Mark Pimentel, MD

    Didactic Lecture

    view details >

    IBS Prime

    Brooks Cash, MD; Philip Schoenfeld, MD;

    Didactic Lecture

    view details >

    Xpert Perspectives on IBS from ACG/WCOG in Orlando

    William D. Chey, MD; Brian E. Lacy, MD; Mark Pimentel, MD

    Didactic Lecture

    view details >

    Xpert Perspectives on OIC from DDW 2017 in Chicago, IL

    William D. Chey, MD

    Didactic Lecture

    view details >

    Negative Effects of Opioids on the Gastrointestinal Tract and The Development of Newer Therapeutics To Overcome Them

    Darren M. Brenner, MD

    Didactic Lecture

    view details >

    Optimizing Management of IBS-C and CIC

    Nicholas J. Talley, MD (chair), Darren M. Brenner, MD, William D. Chey, MD, Philip S. Schoenfeld, MD

    Didactic Lecture

    view details >

    Improving Patient Outcomes in IBS-D: New Evidence on Epidemiology, Pharmacology, and Mgmt

    Lin Chang, MD (chair), William D. Chey, MD, FACG, AGAF, FACP, RFF, Mark Pimentel, MD, FRCP(C), Philip S. Schoenfeld, MD, MSEd, MSc (Epi)

    Didactic Lecture

    view details >

    Beyond Gut Instincts: Applying the latest IBS advances to practice

    William D. Chey, MD, Stanley A Cohen, MD, Nicholas Talley, MD, Mark Pimentel, MD, Philip S. Schoenfeld, MD

    Didactic Lecture

    view details >

    Functional dyspepsia: A new disease model

    Nick Talley, MD

    Didactic Lecture

    view details >

    Integrating Novel Diagnostic Strategies into Practice: Key Points

    Stanley Cohen, MD

    Didactic Lecture

    view details >

    Novel Strategies for IBS-C

    Mark Pimentel, MD

    Didactic Lecture

    view details >

    Management of Severe Constipation: Dysnnergic Defecation and OIC

    Philip Schoenfeld, MD

    Didactic Lecture

    view details >

    Which Diet is Right for IBS?

    William Chey, MD

    Didactic Lecture

    view details >

    Emerging Medical Management Options for IBS-D

    William Chey, MD

    Didactic Lecture

    view details >

    Overview of IBS-C Therapies

    Christine Frissora, MD

    Didactic Lecture

    view details >

    A Primer on the Diagnosis and Management of Functional Dyspepsia

    Brian Lacy, MD

    Didactic Lecture

    view details >

    Distinguishing Celiac Disease, Non-Gluten Sensitivity and IBS

    Lucinda Harris, MD

    Didactic Lecture

    view details >

    Understanding and Managing Gastroparesis

    Linda Nguyen, MD

    Didactic Lecture

    view details >

    Opioid-Induced Bowel Dysfunction

    Darren Brenner, MD

    Didactic Lecture

    view details >

    Xpert Perspectives: New Insights into the Recognition and Management of FGIMDs 2015

    Brooks Cash, MD, William Chey, MD, Mark Pimentel, MD

    Didactic Lecture

    view details >

    Gi News Tonight: Case Discussions on Functional GI and Motility Disorders

    Lawrence Schiller, MD, Lin Chang, MD, Mark Pimentel, MD, Philip Schoenfeld, MD

    Didactic Lecture

    view details >

    Dinner Meetings

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    Audiocasts

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