Abstract

Clostridium difficile-related postinfectious IBS: a case of enteroglial microbiological stalking and/or the solution of a conundrum?

Bassotti G1,2, Macchioni L3, Corazzi L3, Marconi P3, Fettucciari K3. Cell Mol Life Sci. 2017 Dec 28. doi: 10.1007/s00018-017-2736-1. [Epub ahead of print]
 
     
Author information

1 Department of Medicine, University of Perugia Medical School, Perugia, Italy. gabassot@tin.it.

2 Gastroenterology and Hepatology Section, Santa Maria della Misericordia Hospital, Piazzale Menghini, 1, 06156, San Sisto (Perugia), Italy. gabassot@tin.it.

3 Department of Experimental Medicine, University of Perugia Medical School, Perugia, Italy.

Abstract

Post-infectious irritable bowel syndrome is a well-defined pathological entity that develops in about one-third of subjects after an acute infection (bacterial, viral) or parasitic infestation. Only recently it has been documented that an high incidence of post-infectious irritable bowel syndrome occurs after Clostridium difficile infection. However, until now it is not known why in some patients recovered from this infection the gastrointestinal disturbances persist for months or years. Based on our in vitro studies on enteric glial cells exposed to the effects of C. difficile toxin B, we hypothesize that persistence of symptoms up to the development of irritable bowel syndrome might be due to a disturbance/impairment of the correct functions of the enteroglial intestinal network.

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