Abstract

Fecal Microbiota Transplantation in Inflammatory Bowel Disease- a Primer for the Internists

Syal G1, Kashani A2, Shih DQ2. Am J Med. 2018 Mar 29. pii: S0002-9343(18)30283-3. doi: 10.1016/j.amjmed.2018.03.010. [Epub ahead of print]
 
     

Author information

1 Division of Gastroenterology, Department of Internal Medicine, Cedars-Sinai Medical Center, 8730 Alden Drive, 2(nd) Floor East, Los Angeles, CA 90048, USA. Electronic address: Gaurav.syal@cshs.org.

2 Division of Gastroenterology, Department of Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

Abstract

Inflammatory bowel disease consists of disorders characterized by chronic idiopathic bowel inflammation. The concept of host-gut-microbiome interaction in pathogenesis of various complex immune-mediated chronic diseases including inflammatory bowel disease has recently generated immense interest. Mounting evidence confirms alteration of intestinal microflora in patients with inflammatory bowel disease. Thus, restoration of normal gut microbiota has become a focus of basic and clinical research in the recent years. Fecal microbiota transplantation is being explored as one such therapeutic strategy and has shown encouraging results in the management of patients with inflammatory bowel disease.

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