Abstract

Golimumab: clinical update on its use for ulcerative colitis

Gilardi D1, Fiorino G1, Allocca M1, Bravatà I1, Danese S2. Drugs Today (Barc). 2015 Mar;51(3):171-16. doi: 10.1358/dot.2015.51.3.2298240.
 
     
Author information

1IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy. 2IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy. sdanese@hotmail.com.

Abstract

Monoclonal antibodies directed against tumor necrosis factor alpha (anti-TNF-α agents) have dramatically changed the therapeutical approach to inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. A new anti-TNF drug, golimumab, has recently been approved for patients with moderate to severe ulcerative colitis. Its efficacy has been demonstrated by preclinical and clinical studies and the drug showed an efficacy and safety profile in line with the other anti-TNF agents, such as infliximab and adalimumab. This review gives an overview on golimumab in the treatment of moderate to severe ulcerative colitis.

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