Abstract

IBD and the Gut Microbiota-from Bench to Personalized Medicine

Bellaguarda E1, Chang EB. Curr Gastroenterol Rep. 2015 Apr;17(4):439. doi: 10.1007/s11894-015-0439-z.
 
     
Author information

1Division of Gastroenterology and Hepatology, Northwestern University, 676 North Saint Clair suite 1400, Chicago, 60611, IL, USA.

Abstract

Inflammatory bowel diseases (IBD) are chronic relapsing inflammatory disorders involving the gastrointestinal (GI) tract, which arise from the confluence of genetic, immunological, microbial, and environmental factors. Clinical, genetic, and experimental data support the role of gut microbiota in contributing to the etiopathogenesis of these diseases. In IBD, the development of gut dysbiosis and imbalances in host-microbe relationships contribute to the extent, severity, and chronicity of intestinal inflammation. With continued advances in knowledge, technology, bioinformatics tools, and capabilities to define disease subsets, we will be able to lower risk and improve clinical outcomes in IBD through individualized interventions that restore host-microbial balance. This article provides a critical review of the field, based on the latest clinical and experimental information.

© Copyright 2013-2017 GI Health Foundation. All rights reserved.
This site is maintained as an educational resource for US healthcare providers only. Use of this website is governed by the GIHF terms of use and privacy statement.