Abstract

Dietary intake of inulin-type fructans in active and inactive Crohn's disease and healthy controls: a case-control study

Anderson JL1, Hedin CR1, Benjamin JL1, Koutsoumpas A1, Ng SC2, Hart AL3, Forbes A4, Stagg AJ5, Lindsay JO6, Whelan K7. J Crohns Colitis. 2015 Jul 27. pii: jjv136. [Epub ahead of print]
 
     
Author information

1King's College London, Faculty of Life Sciences and Medicine, Diabetes and Nutritional Sciences Division, London , UK. 2St Marks's Hospital, Harrow, Middlesex, UK Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese University of Hong Kong, Hong Kong. 3St Marks's Hospital, Harrow, Middlesex, UK. 4Centre for Gastroenterology and Nutrition, University College London, London, UK. 5Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. 6Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK Digestive Diseases Department, The Royal London Hospital, Barts Health NHS Trust, London , UK. 7King's College London, Faculty of Life Sciences and Medicine, Diabetes and Nutritional Sciences Division, London , UK kevin.whelan@kcl.ac.uk.

Abstract

BACKGROUND AND AIMS: Prebiotic inulin-type fructans are widely consumed in the diet and may have contrasting effects in Crohn's disease by stimulating gut microbiota and/or by generating functional gastrointestinal symptoms. The aim of this study was to measure fructan and oligofructose intakes in patients with active and inactive Crohn's disease compared with healthy controls.

METHODS: Patients with active Crohn's disease (n = 98), inactive Crohn's (n = 99) and healthy controls (n = 106) were recruited to a case-control study. Dietary intake of inulin-type fructans was measured using a specific food frequency questionnaire and was compared between the three groups and between patients with different disease phenotypes (Montreal classification). Associations between intakes and disease activity (Harvey-Bradshaw Index, HBI) were also undertaken.

RESULTS: Patients with active Crohn's disease had lower fructan intakes (median 2.9 g/d, interquartile range [IQR] 1.8) than those with inactive Crohn's (3.6 g/d, 2.1, p = 0.036) or controls (3.9 g/d, 2.1, p = 0.003) and lower oligofructose intakes (2.8 g/d, 1.8) than those with inactive Crohn's (3.5 g/d, 2.2, p = 0.048) or controls (3.8 g/d, 2.1, p = 0.003). There were no differences in intakes related to disease site or behaviour. There were negative correlations between HBI well-being score and fructan intake (ρ = -0.154, p = 0.03) and oligofructose intake (ρ = -0.156, p = 0.028) and for the HBI abdominal pain score and fructan (ρ = -0.164, p = 0.021) and oligofructose intake (ρ = -0.157, p = 0.027).

CONCLUSIONS: Patients with active Crohn's disease consume lower quantities of fructans and oligofructose than their inactive counterparts and healthy controls. The impact of lower intakes of prebiotic fructans on gut microbiota is unknown and warrants further research.

© Copyright 2013-2017 GI Health Foundation. All rights reserved.
This site is maintained as an educational resource for US healthcare providers only. Use of this website is governed by the GIHF terms of use and privacy statement.